Landmark Inns & Hotels 

Kimpton Cardinal Hotel 
Stay inside the iconic R.J. Reynolds Building, the 1929 Art Deco skyscraper that helped inspire New York’s Empire State Building. Following a $60 million restoration, the landmark now houses the 174-room Kimpton Cardinal, where polished interiors meet playful perks. Pets of all kinds stay free, with no size or weight limits. The two-story Rec Room packs in bowling, basketball, billiards, and a spiral slide, while The Katharine Brasserie & Bar brings French-inspired dining downstairs. Step outside, and downtown arts, dining, and nightlife are all close at hand.

Graylyn Estate 
Built in 1932 as the country estate of Bowman and Nathalie Gray, Graylyn feels part European manor, part secluded retreat—yet sits only minutes from downtown. Team Germany made the 55-acre estate its 2026 World Cup base camp, reserving the property for more than a month. Soon after, Graylyn was named the nation’s No. 1 boutique hotel in USA TODAY’s 10Best Readers’ Choice Awards. Its 85 rooms share the estate with gardens, walking trails, guest bicycles, afternoon butterscotch cookies, and unlimited ice cream.

Historic Brookstown Inn 
Housed in an 1837 cotton mill, the Historic Brookstown Inn is part of the Trademark Collection by Wyndham, pairing industrial character with Southern warmth and charm. Its 71 individually laid-out rooms feature exposed beams, original brickwork, lofty ceilings, and cozy seating areas. Old Salem is an easy walk away, while complimentary touches span the day—from a hot Southern breakfast buffet each morning to an evening wine-and-cheese reception and freshly baked cookies with milk at bedtime.

Hotel Indigo 
Hotel Indigo brings boutique style to the 1928 Pepper Building, an Art Deco landmark in the heart of downtown. Local artwork fills the public spaces, while 75 rooms offer plush bedding and spa-inspired showers. The dog-friendly hotel even welcomes four-legged guests with treats at check-in. It’s also home to Sir Winston Restaurant & Wine Loft, making it easy to settle in for dinner and a drink before exploring Fourth Street.

Intimate Stays & B&Bs 

Winston-Salem Historic Inns 
Three historic homes in downtown now operate collectively as Winston-Salem Historic Inns. In the Historic West End, the Summit Street Inns is comprised of two side-by-side properties, the 1887 Ludlow House and the 1893 Sheppard House. Together, they offer 10 individually themed rooms, original fireplaces and stained-glass windows, plus a shared garden patio and thoughtful modern amenities. About a mile away, just off Salem Parkway, the Historic Shaffner Inn offers eight distinctive guest rooms and intimate event space inside a 1907 Queen Anne–Tudor home.

West Salem Art Hotel 
One mile south of downtown, West Salem Art Hotel transforms a 1931 neighborhood grocery into six themed accommodations and shared gallery spaces. Sleep in the Paris-inspired Rose Room, rewind in the VHS Suite—stocked with more than 400 movies—or choose the folk-art-covered Franco Suite. Just next door, West Salem Public House serves coffee by day and local beer, wine, and cocktails after dark.

The Huntley House 
Tucked inside the restored Robert Hall complex in downtown’s Industry Hill, the Huntley House offers five eclectic guest rooms curated with vintage finds and modern touches. Rooms may be booked individually or together, making it flexible for couples, friends, and small groups. Breweries, galleries, maker spaces, and music venues are all within a short walk. 

Zevely Inn B&B (Old Salem)
Sitting in the heart of Old Salem, the 1844 Zevely Inn places guests amid Winston-Salem’s Moravian history. Its 12 individually appointed rooms range from cozy queens to spacious kings, several with working fireplaces. A made-to-order breakfast, complimentary coffee and tea, and fresh-baked cookies round out a stay that feels appropriately timeless.

Mansion on Main (Old Salem) 
The largest home in Old Salem, this meticulously restored 1873 landmark is now a spacious rental for families and small groups. Two kitchens, a library, media room, and formal dining salon offer plenty of room to spread out, while Old Salem’s various attractions begin just outside the door.

Tanglewood Manor House (Clemmons)
Built in 1859 within Tanglewood Park, this Victorian B&B pairs historic elegance with the feel of a full park getaway. Ten individually designed rooms fill the Manor House, with additional lodging in a guest house, cottages, and apartments. Golf courses, trails, horse stables, playgrounds, and seasonal recreation are all just outside.

Keep Exploring Local History

Want to keep traveling through time? Explore the museums, landmarks, and living-history experiences by visiting our History Buffs page. 

Also be sure to check our online Events Calendar to see what’s happening during your stay—from history tours and museum exhibits to festivals, concerts, and more.